Miranda Richardson showed a talent and desire to "turn herself into" other people at an early age, performing in school plays. She has referred to it as "an emotional fusion; you think yourself into them". This mimicry could be of school friends or film stars.

She left school at the age of 17, and originally intended becoming a vet. She also considered studying English literature in college, but decided to concentrate on drama and enrolled at the Bristol Old Vic Theatre School. After three years she graduated and moved into repertory theatre. She became affiliated with the Library Theatre in Manchester in 1979, where she became an assistant stage manager. She obtained her Equity card, and after several regional productions, first appeared on the London stage (Moving at Queens Theatre) in 1981. British television roles soon followed, and then film.

Since then, Miranda has moved into the international arena, and has made films in America, France and Spain. Television work (on both sides of the Atlantic) continues, as does some stage work. Her roles are diverse, but powerful and engaging. She has been quoted as stating "what I basically like is doing things I haven't done before" and this continually comes through in the variety of roles she has played in her career. She is also selective in the roles she takes, being uninterested in performing in the standard Hollywood fare, and preferring more offbeat roles. She was approached to play the Glenn Close role in Fatal Attraction (1987), but found it "regressive in its attitudes". Her attitude is summed up by a quote from an interview that appeared in the New York Times (Dec 27 1992): "I would rather do many small roles on TV, stage or film than one blockbuster that made me rich but had no acting. And if that's the choice I have to make, I think I've already made it".

Her hobbies include drawing, walking, gardening, fashion, falconry, and music. She, by her own admission, is a loner and lives rather modestly. An actor who studied with Ms Richardson at the Bristol Old Vic Theatre in the late 1970s described her as "a strong minded, specially gifted, rather pretty young woman who enjoys wearing jewelry. She wore toe rings, which in the late 1970s and especially in England, were a rarity and considered rather racy." He also remarked on her drive, even then, to be an actress of the highest caliber.