Dominique Swain debuted her film career in the controversial remake of Vladimir Nabokov's novel and Stanley Kubrick's film Lolita by director Adrian Lyne. It was a powerful first performance by the young actress, Lyne had seen her performance on a videotape audition she put together with a friend while she was between agents, selecting her from a pool of more than 2500 actresses vying for the role. Lyne was charmed by her and her reading directly from the novel as opposed to the script. Despite a phenomenal performance opposite Jeremy Irons as Humbert and Melanie Griffith as Lolita's mother, the film faced a great deal of controversy due to its subject matter as networks pulled away from backing wide theatrical release. After some delays, it was eventually premiered to US audiences on the Showtime network followed by a limited theatrical release.

Since then she has gone on to act and star in close to 100 other films, including Face/Off, Girl and Alpha Dog. Recently she has joined Cameo where her fans can directly reach out to her for personal videos or direct message chats.